Specifically, cyanide binds rapidly with cytochrome a3, a component of the cytochrome c oxidase complex in mitochondria. In the absence of rapid and adequate treatment, exposure to a high dose of cyanide can result in death within minutes due to the inhibition of cytochrome oxidase resulting in arrest of cellular respiration. Hydroxocobalamin Mechanism of actionĬyanide is an extremely toxic poison. Evidence-based medicine for Chemical Defense - including efficacy and safety A. Hydroxocobalamin is indicated as an antidote in patients with known or suspected cyanide poisoning. Chemical Defense therapeutic area(s) - including key possible uses Name of Chemical Defense therapeutic agent/device
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